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Ultrasonic Homogenizers (Sonicators)

Ultrasonic homogenizers, commonly referred to as "sonicators," disrupt tissues and cells through cavitation and ultrasonic waves.  Basically, an ultrasonic homogenizer has a tip which very rapidly vibrates, causing bubbles in the surrounding solution to rapidly form and collapse.  This creates shear and shock waves which tear apart cells and particles.

Ultrasonics / sonicators are great for breaking apart cells and subcellular structures in suspension.  They are not good for homogenizing intact tissue.  Ultrasonic homogenizers can also shear DNA, which could be a good thing or a bad thing depending on your application.  Other applications include creating emulsions, dispersing nanoparticles, and reducing the size of particles in suspension.  Sonicators generate a significant amount of heat so they may not work well with temperature-sensitive samples.  Acoustic enclosures are highly recommended; after all, you're homogenizing using high-powered sound waves.

Uncertain if an ultrasonic is the right homogenizer for your application?  We can help!  Ask us anything.